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At IRBM, we have a formidable team. If you are interested in joining a dynamic business and scientific environment, please send an email to:  curricula@irbm.it  This email address is being protected from spambots. You need JavaScript enabled to view it or to apply for the following Job Vacancies.

For sending CV, please send an email to:  curricula@irbm.it  or apply for the following Job Vacancies.

 

SCIENTIFIC DEPT.

Scientist biology – Ref. 139 AHuman Stem Cell Biology – Ref. 137 AMolecular Biology of protein post-translational modifications – Ref. 137BImmunoassay & Molecular Biology Scientist – Ref. 134 BLab Head Screening – Ref. 131AChemistry DMPK Scientist - Ref. 101A

We are seeking a highly motivated, result-driven scientist to join our efforts in drug discovery and development.

The successful candidate will use a wide range of techniques to identify and validate novel targets and to drive the preclinical development of drugs, small molecules or biologics, from lead identification to lead optimization and clinical candidate selection. The successful candidate will have excellent analytical, communication, organizational and presentation skills.

He/She will have broad knowledge and experience of the molecular and cellular biology methodologies and will collaborate with other team members to advance our R&D discovery programs. Previous experience in biotech/pharma and in drug discovery and development is considered a plus. Expertise in oncology and/or rare genetic disorders is preferable.

Key responsibilities:

  • Responsible for driving internal programs in a multidisciplinary research team
  • Participate in cross-functional research to identify and validate novel targets and translate these findings into novel drugs to benefit patients.
  • Ensure scientific excellence, quality and completeness of programs.
  • Maintain notebooks and other records with clarity and completeness.


Skills:

  • Organized, self-motivated, able to work independently.
  • Ability to multi-task and deliver results in a timely manner to drive projects forward
  • Good knowledge of written and spoken English is required.
  • Highly proficient in standard techniques in molecular biology, biochemistry and mammalian cell culture
  • Familiarity in protein purification, column chromatography and protein characterization procedures such as SDS-PAGE, peptide mapping, Western Blot and ELISA is considered a plus.


Minimum Requirements:

Required: Master Degree or PhD in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related fields.

Preferred: Our ideal candidate will have a PhD or equivalent experience in Biology, Biotechnology or related fields with a minimum of 2 years relevant experience in an equivalent role.


Location
: the position will be based at IRBM Science Park in Napoli, Italy


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We are seeking an experienced cell biologist to join our Biology Department.
As a key member of IRBM’s Biology team this role will involve directing and delivering on the Company’s internal and external drug discovery objectives.

The successful candidate is expected to have experience in the implementation, maintenance, differentiation and characterization of human stem cells and their differentiation into neuronal cell types. Exposure to genome editing and characterization of mutant human stem cell lines is a definite plus. The ideal candidate will have a PhD or equivalent experience and a minimum of 2 years of hands-on experience in the culture, manipulation and differentiation of human stem cells into neurons and the implementation of these neuronal models for functional studies. The successful candidate will join a dynamic, multidisciplinary team dedicated to the development of novel therapeutic strategies for Huntington’s disease leveraging post-translational modifications of Huntingtin protein.

Strong communication skills will be required to enable successful management of both associate and PhD scientists as well as the coordination of external collaborations and CRO’s. This position will suit a highly motivated, innovative and strong team player with experience and a proven track record of advancing drug discovery projects.

Minimum requirements:

  • PhD in Cell Biology or a related field, with significant post-doctoral experience. Industrial experience in the pharmaceutical or biotech sector is a bonus;
  • Extensive experience in the maintenance and manipulation of human embryonic stem cell lines and in their use in the development of models to study neuronal differentiation and neurodegeneration
  • Management and leadership skills, ability to provide supervision and mentorship;
  • Strong team ethic and focus on delivering to agreed project timelines;
  • Motivated and passionate about conducting high quality scientific research.

IRBM is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Location

The position will be based at IRBM Science Park headquarters in Pomezia (Rome), Italy

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We are seeking an experienced cell biologist to join our Biology Department.
As a key member of IRBM’s Biology team this role will involve directing and delivering on the Company’s internal and external drug discovery objectives.

The successful candidate is expected to have experience in the functional analysis of protein post-translational modifications, with particular relevance to kinase-mediated signaling and phosphorylation studies. The ideal candidate will have a PhD or equivalent experience, will be versed in the genetic and pharmacological analysis of intracellular signal transduction, and have demonstrable, hands-on experience of one or more of the following: genome editing to introduce point mutations to study PTM function; intrabody technology to selectively target post-translationally modified variants of proteins of interest; Proximity Ligation to identify and detect specific PTMs within cells. The successful candidate will join a dynamic, multidisciplinary team dedicated to the development of novel therapeutic strategies for Huntington’s disease leveraging post-translational modifications of Huntingtin protein.

Strong communication skills will be required to enable successful management of both associate and PhD scientists as well as the coordination of external collaborations and CRO’s. This position will suit a highly motivated, innovative and strong team player with experience and a proven track record of advancing drug discovery projects.

Minimum requirements:

  • PhD in Biochemistry, Molecular Biology or a related field, with significant post-doctoral experience. Industrial experience in the pharmaceutical or biotech sector is a bonus;
  • Extensive experience in the functional analysis/mechanistic aspects of signal transduction mediated by post-translational modifications, and of kinase-mediated signaling in particular;
  • Management and leadership skills, ability to provide supervision and mentorship;
  • Strong team ethic and focus on delivering to agreed project timelines;
  • Motivated and passionate about conducting high quality scientific research.

Location

The position will be based at IRBM Science Park headquarters in Pomezia (Rome), Italy

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We are seeking a Postdoctoral Biologist to join our group in the Neuroscience Department at IRBM Science Park. This laboratory-based position is within a Team actively engaged in the study of post-translational modifications of proteins associated with neurodegenerative proteinopathies, using state-of-the-art immunoassay methodologies, in collaboration with international partners.

The successful candidate will possess a PhD, post-doctoral experience (preferably in an international context) and a proven background in antibody characterization, immunoassay development and cell and molecular biology methodologies. He/she will have a strong capacity to work to deadlines and according to agreed plans, teamworking ability and a highly results-oriented approach. He/She will be highly motivated towards conducting high quality scientific research using latest generation protein detection platforms, applied to the development of ultra-sensitive assays for the quantification of proteins of relevance to neurodegenerative disorders. Excellent presentation and communication skills and high proficiency in English are also required.

Minimum Requirements:

  • PhD in Biology (on a subject relevant to the job description) and at least one year post-doctoral experience
  • Extensive hands-on expertise in antibody characterization and protein detection methodologies based on immunoassay platforms 
  • Knowledge of the drug discovery process
  • Flexible attitude, excellent interpersonal skills and teamwork ability
  • Excellent communication skills in English

 

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As a key member of IRBM’s Screening Technologies department this role will involve directing and delivering on the Company’s internal and external drug discovery objectives. The successful Candidate is expected to have a good experience in assay development and optimization both for biochemical and cell based assays and a good understanding on compound testing and potency determination. She/He will actively lead and/or contribute to project teams tasked with rapidly advancing drug discovery programs. A strong background in biology with a special focus on assays is expected, likely to PhD level or to an equivalent industry experience. Strong communication skills will be required to enable successful management of associates as well as the coordination of external collaborations and CRO’s. This position will suit a highly motivated, innovative and strong team player.

Minimum Requirements:

  • PhD in biology (or related fields) or M.Sc. with at least five years of experience
  • proven experience with both biochemical and cell based assays
  • strong attitude to automation and informatics
  • understanding of drug discovery assay requirements
  • basics of chemical compound management
  • management and leadership skills, ability to provide supervision and mentorship

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Design, conduct and analyze in vivo and/or in vitro DMPK studies to support drug discovery and preclinical development. Obtain/interpret bioanalytical/pharmacokinetic and/ or in vitro findings, write reports, make presentations, and communicate with other DMPK and Med Chem scientists. Requires PhD or MS and 2+ years industry experience with in vivo and/or in vitro DMPK; knowledge of enzyme kinetics and hands-on DMPK skills including bioanalytical method development using LC/MS/MS; drug quantitation in various matrices such as plasma and tissues; sample preparation using liquid handling robots, and computational PK analysis using Watson or similar software. Previous experience in the design of in vivo experiments or metabolite identification is a plus.

Minimum Requirements:

The candidate must have: Hands-on experience on mass spectrometry and HPLC as applied to in vitro & in vivo drug metabolism. Working knowledge of other instrumentation including UPLC, radiometric, LSC, fluorescence detectors is a plus.

Innovative, independent and goal-oriented; able to plan and execute own research while being a good team player. Able to work in interdisciplinary and multicultural teams where English is the common language.

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INFORMATION TECHNOLOGY DEPT.

Analyst / Programmer Microsoft Dynamic NAV - Ref. 124AMicrosoft Dynamics NAV Developer Jr - Ref. 124BScientific Application Specialist - Ref. 129AAssociate IT Scientific Application Specialist - Ref. 120A

Job Description:

We are looking for a motivated, flexible and experienced analyst programmer with two year minimum of experience as a MS Dynamic NAV consultant. The ideal candidate will support ERP project initiatives, he/she will participate in the maintenance and support activities already in production, he/she will develop new features or deployment, roll-outs and release upgrade.

The ideal candidate also has a good knowledge of English (written and spoken), he/she is a good team player, he/she is attentive to details and methodical and he/she has strong analysis and problem solving skills.

Minimum Requirements:

  • Master’s or Diploma degree in Computer Engineering or an equivalent;
  • Excellent knowledge of MS Dynamic Navision;
  • Good knowledge of administration and organization, active and passive cycle, costing methods, basics of accounting, logistics, stock records;
  • Good knowledge of DB Oracle;
  • Knowledge of IIS, SQL Server, Exchange and related issues;
  • Good knowledge of C++ language;
  • Knowledge of MS Sharepoint;
  • Good knowledge of MS Office package in particular MS Excel;

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Job Description:

We are seeking a Microsoft Dynamics NAV Developer Jr with 2-3 years in developing NAV personalizations. An excellent knowledge of Microsoft’s world is required especially of Dynamics NAV RTC, .NET and SQL Server..

Skills requested: 

  • Experience in Dynamics NAV RTC development;
  • Experience in.NET programming;
  • Knowledge of SQL Server;
  • Knowledge of NAV website;
  • Experience in managing NAV web services ;
  • Knowledge of Finance, Purchasing and Logistics workflow;

Minimum qualification: 

  • Bachelor’s degree (Laurea triennale) 3 years;

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Job Description:

We are seeking a scientific application specialist with 5-8 years working experience in implementation, configuration and development of solutions based on Dotmatics. The successful candidate will possess excellent knowledge in the implementation of a system for the registration of the molecular structures in a complex database (Compound Registration and Information Management System), with web interface based on Dotmatics browser.

 

Skills requested: 

  • Installation and configuration Dotmatics suite;
  • Oracle DBA;
  • Development and management of Webserver Tomcat
  • Demonstrated team working experience in providing high-level solutions;
  • Understanding of web architectures and relational database;
  • Over 5+ years of working experience in developing software in scientific companies (in pharmaceutical /biotech sectors is desirable);
  • Comprehension of chemistry and biology;
  • Motivated, ambitious and self starter

Minimum qualification:

  • Laurea or PhD in IT, Science or Mathematics;

Responsibilities: 

  • Working productively in a team ;
  • Detecting the requirements for the personalization of requests from internal users and external clients ;
  • Training of the users on the utilisation and the personalization of Dotmatics Suite;
  • Presenting advantages of Dotmatics Suite, explaining the technical architecture and its application ;
  • Finding and proposing new projects and/or personalizations ;

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We are looking for a motivated, flexible and experienced Java Programmer with a background in Chemistry/Pharmacology.
The candidate should have some knowledge of relational databases and Web development.
His activities will be focused on the development of scientific applications, integration tools for Microsoft Office, and scripting.
Support and maintenance activities will be complementary to the development activity.
Good interpersonal skills and reporting abilities are required.

Minimum Requirements:

  • Degree in Chemistry/Pharmacology or Chemical Engineering (or a different Engineering with proved experience in Chemistry)
  • Experienced in Java Programming ( or C/ C++ object oriented programming)
  • Knowledge of the Technical English language (reading and writing English documentation)
  • Knowledge of Web Development technologies and relational Databases (preferential requirements).

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SCIENTIFIC EQUIPMENT SERVICES DEPT.

Scientific Equipment Services Specialist – Ref. 133 A

Job description:

IRBM Science Park S.p.A. is a biomedical research Company that provides a broad spectrum of research services for Drug Discovery, Organic Chemistry, Biomedical Sciences and Biotechnology Applications, together with internal R&D projects endorsed by decades of industry experience.

We seek a young, motivated and enthusiastic:

Scientific Equipment Services Specialist

 

Position:

He/she will part of a dynamic team of multi-skilled technical staff and will report directly to the Head of Department.

 

Main duties:

  • Ensuring the correct and consistent implementation of planned/unplanned maintenance programs by managing the personnel involved in carrying out maintenance and calibration and/or by assigning the task to third parties;
  • Managing ordinary and extraordinary maintenance programs;
  • Implementing a preventive maintenance strategy;
  • Collaborating with the Site Services and Safety Department and the Information Technology Department for a cost budgeting analysis aimed to rationalize the maintenance operations and all related procedures in collaboration with Site Services and Safety and IT. Reports of the activities preparation;
  • Carrying out the supervision and verification of the maintenance operations, coordinating the team activities in collaboration with the laboratories’ managers, the IT and Site Services & Safety Departments’ staff as well as ensuring the applicable regulations in force on Quality, Safety, Hygiene and Environmental Protection;
  • Ensuring a correct and consistent supply of the spare parts inventory by considering all budgetary functions and by defining the needs with the laboratories’ managers as well as with the maintenance services’ contractors.

 

IRBM Science Park is a private owned company leading a group of five affiliates and it is renowned for world-class science and personnel. Joining a growing innovative company with such a successful story would be a great opportunity for a young and motivated candidate.

 

Requirements:

Our ideal candidate will be qualified with a Degree in Engineering, Physics, Chemistry, Biology or Scientific Technical Diploma and have a minimum of 3 years’ relevant experience in the same role.

He/she will have a strong knowledge in the field of maintenance and repair of the supplied equipment in research laboratories and a technical support experience in research and production laboratories as part of analytical instruments such as HPLC, UPLC and GC.

He/she will have experience as basic user, but also on maintenance of laboratory instrumentation such as HPLC, UPLC, gas chromatographs, spectrophotometers, NMR, as well as integrated systems for laboratory automation and analytical instrumentation, support such as scales, centrifuges, incubators, fume hoods, industrial refrigerator (-80).

 

Skills:

  • Proficiency with metrological techniques and the main certifications of tools and equipment;
  • Proficiency with quality systems, in particular GMP, ISO 9001 and ISO 13485;
  • Good direct intervention capacity on the instrumentation for the installation, setup, calibration and repair ability on both, the hardware and the software of the instrument;
  • Autonomy, precision, ability to synthesize, problem solving, goal-orientation and excellent predisposition to work in team;
  • Ability to work under pressure and to tight deadlines;
  • Good/excellent level of written and spoken English;
  • Discretion and understanding of confidentiality issues.

 

Location:

The position will be based at IRBM Science Park headquarters in Pomezia (Rome), Italy

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ADMINISTRATION DEPT.

Buyer Specialist – Ref. 134 A

We are seeking a Buyer Specialist for the company’s Purchasing Department.
The successful candidate should possess a Master’s degree in Economics and Business or in a related degree, and will ideally have at least six years of work experience in a big-pharma and/or multinational setting. The candidate will report directly to the Managing Director, and will be responsible for:

  • Coordinating the daily operations of purchasing functions;
  • Respecting, monitoring, and implementing policies and procedures related to areas of responsibility;
  • Ensuring that orders are placed and received in a timely manner and at the correct cost;
  • Monitoring quotes, orders, and order confirmations;
  • Assisting colleagues/teams with the resolution of purchase order discrepancies and, in particular, the scientific team and the Accounts Payable staff;
  • Financial and product data in order to maximize performance generation and reduce company costs;
  • Assisting Managers on specific projects and, in particular, on Master Agreements;
  • Complying with safety policies and procedures, regulatory requirements, as well as participating in department safety activities;
  • Performing other duties as directed or as necessary in order to ensure daily operations, data analysis, and savings;
  • Processing and optimizing purchasing orders and check deliveries;
  • Maintaining financial and purchasing files and records;
  • Preparing monthly reports and reporting on variances.

A sound knowledge of standard purchasing procedures is required, as well as the ability to work as part of a team.

Minimum Requirements:

  • Proficiency with standard computer software packages, in particular with Excel, and ERP purchasing software
  • An advanced level of written and spoken English

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PROMIDIS

Laboratory Technician (Promidis) – Ref. 138 AChemist (Promidis) – Ref. 138 B

Job description:

Promidis S.r.l. is a privately owned company, part of the IRBM group, focused on the identification of innovative drugs in high, unmet medical need areas, and on offering a highly competitive spectrum of drug discovery activities. The company is located within the San Raffaele Hospital in Milan.

Promidis S.r.l. is seeking a Laboratory Technician with a strong chemistry aptitude in analytical and organic chemistry.

The successful candidate, is a self-started and motivated individual able to efficiently analyse, prioritize and manage multiple tasks. More specifically, under the supervision of senior chemists, s/he will develop HPLC methods for both analytical and preparative purposes. Besides, s/he will routinely and effectively maintain laboratories in terms of supplies, handling waste, solvents and raw materials. The ideal candidate will have a technical high school diploma earned with high marks. S/he possesses excellent interpersonal skills to work both independently and within a team along with problem-solving aptitude and diagnostic troubleshooting to resolve technical issues. Finally, s/he has good written and verbal communication skills in English.

Minimum Requirements:

  • Technical high school diploma;
  • Technical knowledge of common purification techniques (chromatography and HPLC);
  • Excellent documentation record keeping ability;
  • Motivated and passionate about conducting high quality scientific research.

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Job description:

Promidis S.r.l. is a privately owned company, part of the IRBM group, focused on the identification of innovative drugs in high, unmet medical need areas, and on offering a highly competitive spectrum of drug discovery activities. The company is located within the San Raffaele Hospital in Milan.

Promidis S.r.l. is seeking a Chemist with a solid background in organic and analytical chemistry.

As member of the chemistry team, the successful candidate will be involved in the planning and execution of multi-step organic synthesis to generate new chemical entities at support of the active series of drug discovery projects, aimed at selecting high quality drug candidates. The ideal candidate will have a MS Degree in Chemistry or CFT with proven ability to design, synthesize, purify and characterize novel organic molecules. The knowledge of the modern lead optimization concepts, to design chemical strategies addressing biological activity and ADME/toxicology properties, is viewed as preferential. We particularly seek individuals who have excellent interpersonal skills to work both independently and within a team. Besides, working in a dynamic environment, flexibility, strong can do aptitude and excellent written and verbal communication skills in English, are viewed as essential.

Minimum Requirements:

  • MS or equivalent qualification in Chemistry or CTF;
  • Good laboratory skills, ideally including knowledge of parallel synthesis approaches;
  • Knowledge of common purification techniques (chromatography and HPLC);
  • Knowledge and experience in structure elucidations of organic molecules by NMR and MS;
  • Ability to interact with team but work independently towards defined goals and timelines;
  • Motivated and passionate about conducting high quality scientific research.

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