Assessment of the in vitro permeability in the PBECs/As model of small molecules


We developed and characterized a 2D cell culture model for the prediction of CNS drug permeability in vivo and for ranking and prioritization of compounds by permeability. This system discriminated among drugs of different permeability and with different mechanisms of influx/efflux. It is currently used as an in vitro tool to explore transport of investigational compounds across BBB.

In addition the system has been validated to examine other aspects of BBB function and to evaluate assay-receptor mediated transcytosis of large molecules like proteins and antibodies.

PBECs/As model as an assay to study ligands for different receptors and transporters