To provide quantitative (PK parameters) and qualitative data (screening Met ID) within the same run


We use high resolution mass spectrometry (HRMS, Orbitrap technology) to combine accurate and high sensitivity quantitation of a drug candidate in biological samples and metabolite identification. Pharmacokinetics parameters and metabolite ID data are simultaneously obtained by the same LC-MS run using an optimized LC-MS method for targeted and untargeted detection, providing a reduction of analysis time, resources and animal use. A robust and efficient fully automated workflow is in operation for routine pharmacokinetic studies.

Use of ‘dilute-and-shoot’ liquid chromatography-high resolution mass spectrometry in preclinical research: application to a DMPK study of perhexiline in mouse plasma. J Pharm Biomed Anal. 2016 Jan 25;118:70-80